Open in a separate window. Sixty teeth were examined, in 30 patients taking statins and 30 not taking statins control. Therefore, there is a current trend to include apical periodontitis in the group of human infectious diseases caused by bacterial biofilms. Selected endodontic pathogens in the apical third of infected root canals: Even so, one can select 10—20 species that are virtually always among the most frequently detected species in most well-conducted studies about the endodontic microbiota.

Based on cross-sectional studies, several species have emerged as candidate or putative endodontic pathogens, and the labels candidate or putative should be preserved while a definite role in disease causation is not determined. Chronic apical periodontitis Primary infections are conspicuously dominated by anaerobic bacteria organized in a mixed community. Exploiting molecular methods to explore endodontic infections: Although fungi, archaea, and viruses have been found in association with some forms of apical periodontitis, bacteria are the main microbial etiologic agents of this disease. Bacteria settled in the apical root canal are in a strategic position to induce damage to the periradicular tissues.

Pseudomonas aeruginosa Parvimonas micra Enteric rods Peptostreptococcus spp. Molecular biology methods have caused a great impact in the knowledge of the bacterial diversity in endodontic infections Detection of Filifactor alocis in endodontic infections associated with different forms of periradicular diseases.

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This is because different species may apparently occupy the same niche in different communities as suggested by studies showing a high interindividual variability in the endodontic bacterial communities associated with the same disease condition 18periodontitos Herpesviruses in abscesses and cellulitis of endodontic origin. Healing was determined using the periapical index.

Fungi in endodontic infections. Therefore, there is a current trend to include apical periodontitis in the group of human infectious oeriodontitis caused by bacterial biofilms.


Extensive bone loss associated with dissertatio infection with Bacteroides gingivalis: All disserrtation findings indicate that the microbiota of root canal-treated teeth with apical periodontitis is more complex than previously anticipated by culture studies.

Information provided by these methods has the potential to disclose patterns of molecules associated with diverse clinical conditions, helping establish outcome aoical based not only in specific species combinations or communities, but perhaps even more importantly on the resultant products of these consortia. The diversity of the bacterial communities has been found to differ significantly when apicsl microbiota of chronic apical periodontitis and acute apical abscesses are periodonritis Propionibacterium propionicum Pseudoramibacter alactolyticus Eikenella corrodens Pseudoramibacter alactolyticus Filifactor alocis Fusobacterium nucleatum Synergistes spp.

Unfortunately, open-ended molecular approaches for identification of bacteria in polymicrobial infections are still time-consuming but further technological advances have the potential to expedite bacterial identification by these techniques. The question as to whether the extraradicular infection is dependent on or independent of the intraradicular infections assumes special relevance from a therapeutic standpoint.

Exploiting molecular methods to explore endodontic infections: Histologic investigation of root canal-treated teeth with apical periodontitis: The extraradicular occurrence of several anaerobic bacteria has also been reported in post-treatment apical periodontitis lesions — Overall, the bacterial density per canal varies from 10 3 to 10 8 22939 — Two calibrated endodontists assessed outcomes blinded to preoperative status.

The Association of Statin Intake and Healing of Apical Periodontitis After Root Canal Treatment

Several culture-difficult species have been consistently included in the set of candidate endodontic pathogens only after the advent of molecular techniques for bacterial identification. Molecular and cultural analysis of the microflora associated with endodontic infections.

Thus far, there is no strong evidence reporting on the specific involvement of a single species with any particular sign or symptom of apical periodontitis. Bacterial diversity in persistent periapical lesions on root-filled teeth.


Anti-microbial treatment of infected root canals using mechanical instrumentation and chemicals for disinfection does not always lead to complete bacterial elimination and treatment failure may therefore result.

Fluorescence in situ hybridization FISH for direct visualization of bacteria in periapical lesions of asymptomatic root-filled teeth. As certain bacteria appear more resilient to endodontic treatment than others, the present thesis addresses the species that can most frequently be isolated after treatment and explores mechanisms, which could potentially afford these organisms resistance to anti-microbial treatment measures.

Microbial involvement with treatment failures is supported by two strong evidence-based arguments. For instance, the acute apical abscess is usually dependent on the intraradicular infection, i.

dissertation apical periodontitis

Conflict of interest and funding There is no conflict of interest in the present study for any of the authors. In advanced stages of the infectious process, bacterial organizations resembling biofilms can be observed adhered to the dentinal root canal walls 9 — 11 Fig.

Distinctive features of the microbiota associated with different forms of apical periodontitis

Chavez de Paz LE. Dissertxtion infections are caused by microorganisms that colonize the necrotic pulp tissue. Real-time quantitative polymerase chain reaction and culture analyses of Enterococcus faecalis in root canals.

dissertation apical periodontitis

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